Background

Data on COVID-19 vaccine effectiveness (VE) among healthcare workers (HCWs) during periods of delta variant predominance are limited. Literature accounting for other potential determinants of infection rates is even more scarce.

Objective

To investigate the continued effectiveness of COVID-19 vaccination during the Delta variant predominance in a diverse and urban healthcare setting.

Methods and Findings

A community-based healthcare system in Massachusetts runs a COVID-19 vaccination program for employees (described previously (1)), with the Pfizer vaccine starting on December 16, Moderna on December 23, 2020, and J&J/Janssen in February 2021. Vaccination was available to all workers regardless of their in-person/remote working status from December 29, 2020. In addition, the system announced a vaccine mandate on August 16, 2021, which requires employees to receive their final dose by October 18, 2021 barring an approved religious or medical exemption.

We followed all actively serving HCWs in the system from December 16, 2020 to September 30, 2021, excluding those with prior COVID-19 infection from the main analyses. The outcome was having a positive PCR assay during the study period documented by the healthcare system’s Occupational Health department (2). The established master database, comprised of workers’ demographics, prior infection, de novo PCR positivity, vaccination (validated by the Massachusetts Immunization Information System and/or the healthcare system’s medical records), and human resource administrative data, has been previously described (1, 2). For each HCW, we calculated the person-days at risk and categorized them according to vaccination status. A HCW’s follow-up person-days were censored at the end of the study period, his/her termination date, the date tested positive for COVID, or the date he/she received a 3rd vaccine dose, whichever came first.

The Andersen-Gill extension of the Cox proportional hazards models were built to account for correlated data. We further adjusted for age, sex, race, and the Massachusetts statewide 7-day average of tested COVID cases (3) on the date the first dose was given to control for background rates. We estimated VE by calculating 100%×(1−hazard ratio). The R software (version 3.6.3) was used for statistical analyses.

A total of 4,615 HCWs (average age of 45.0±13.3 years and female predominance (76.0%)) contributed to 1,152,486 person-days at risk during the study period. Forty-five percent of the study population was non-White (including 20% African American, 13.5% Hispanic, and 9.0% Asian). Of all HCWs, 4,418 (95.7%) had received at least one dose by the end of the study. Among them, 58.3% got Moderna, 39.4% Pfizer, 2.3% J&J/Janssen, and one (0.02%) got mixed doses of J&J/Janssen and Moderna. The results showed that throughout the study period, for fully vaccinated HCWs the VE is 82.3% (95% CI: 75.1–87.4%) after multivariable adjustment (Table, Figure).

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Figure.The Kaplan-Meier curve for the survival (i.e. infection-free) person-days across the four categories based on vaccination status

We further conducted a secondary analysis limiting the study period from July 1, 2021 to September 30, 2021, corresponding to delta variant predominance in Massachusetts (4). We observed an incidence rate of 5.8/10,000 (15 events out of 25,910 person-days) for unvaccinated person-days and 1.3/10,000 (39 events out of 308,267 person-days) for 14 days after fully vaccinated, resulting in an adjusted VE of 76.5% (95% CI: 40.9–90.6%).

When we examined HCWs (n=423) with infections occurring before vaccination, no re-infection was observed, accumulating 74,557 re-infection-free person-days (starting 10 days after initial infection and censoring at the date of receiving their first vaccine dose). Further, after vaccination, previously infected HCWs did not contribute any breakthrough infection events among the vaccinated HCWs.

Discussion

To our knowledge, this study is one of the first in healthcare settings regarding continued VE during delta variant predominance. Our work also provides further evidence of naturally acquired immunity. We found similar VE against the delta variant, 76%, compared to another study’s findings, 66% (5). Strengths included accounting for covariates and information bias such as demographics and background incidence, a multiethnic study population, consistent COVID-19 screening criteria, and well-validated vaccination records. Nonetheless, we did not examine individual manufacturers’ VE due to a limited power.